The effects of dorzolamide on choroidal and retinal perfusion in non-exudative age related macular degeneration

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The effects of dorzolamide on choroidal and retinal perfusion in non-exudative age related macular degeneration.

AIM To comprehensively evaluate the effects of dorzolamide on the choroidal and retinal circulation in patients with age related macular degeneration (AMD). METHODS In this randomised, double masked, parallel study, 36 non-exudative AMD patients were randomised in a 2 to 1 fashion to placebo versus topical dorzolamide and underwent assessment of their choroidal and retinal circulation. Scanni...

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Choroidal perfusion perturbations in non-neovascular age related macular degeneration.

AIM Choroidal perfusion, affected in age related macular degeneration (AMD), is difficult to objectively assess given the overlying retinal circulation. This study more objectively compared choroidal perfusion parameters in a group with non-neovascular AMD to an unaffected age matched control group. METHODS 21 non-neovascular AMD subjects and 21 age matched control subjects without evidence o...

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Measurement of Choroidal Neovascular Area in Age-Related Macular Degeneration using Modified Otsu’s Thresholding Method

Introduction: Age-related Macular Degeneration (AMD) is one of the most important causes of irreversible  blindness in the developed world and  prevents the affected  person from  performing simple tasks such  as  reading,  driving  and  facial  recognition.  In  the  AMD,  new  blood  vessels  grow  underneath  the  retina  in  a  process  called  choroidal  neovascularisation  (CNV).  There  ...

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Retinal and choroidal thickness in early age-related macular degeneration.

PURPOSE To compare retinal thickness and choroidal thickness at increasing retinal eccentricity in individuals with early age-related macular degeneration (AMD) and in healthy controls using enhanced choroidal penetration, 3-dimensional optical coherence tomography at 1060 nm. DESIGN Cross-sectional study. METHODS Individuals with early AMD (n = 16; mean age, 71.6 ± 8.5 years) and a compari...

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The Study of Serum Asymmetric Dimethylarginine Concentrations in the Different Paraoxonase Phenotypes of Exudative Age-related Macular Degeneration Disease

Background and Aims: Age-related macular degeneration (ARMD) is a degenerative retinal disorder that causes progressive loss of central vision in older adults. The study aimed to determine the effect of asymmetric dimethylarginine (ADMA) as oxidizing metabolite and paraoxonase (PON1) activity within its phenotypes as an antioxidant agent in the development of such multifactorial disease. Mater...

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ژورنال

عنوان ژورنال: British Journal of Ophthalmology

سال: 2003

ISSN: 0007-1161

DOI: 10.1136/bjo.87.6.753